Instrumentation

Pharmaceutical / Biopharmaceutical Instrumentation

Type of Instrumentation

# of Units

Liquid Chromatography
Agilent/Waters/Thermo Scientific HPLCs including: 125
    Waters Acquity (UPLC)
4
    Agilent Thermo Scientific UHPLCs
15
Dionex ICS-3000 Ion Chromatograph (IC) 5
Beckman ProteomeLab PA 800 Capillary Electrophoresis (CE) Instrument 1
Laser-Induced Fluorescence (LIF) 1
HPLC Fraction Collector 1
HPLC Detectors Including: 144
    Ultraviolet (UV)
105
    Refractive Index (RI)
13
    Fluorescence (FL)
7
    Photodiode Array (PDA)
9
    Multi-angle Light Scattering (MALS)
1
    Electrochemical (ECD)
1
    Evaporative Light Scattering (ELSD)
2
    Corona Charged Aerosol (CAD+)
6
Mass Spectrometry
Thermo Scientific Accela LC/LTQ XL Ion Trap 1
Thermo Scientific Accela LC/LTQ Orbitrap XL 1
Thermo Scientific Accela LC/TSQ Vantage LC/MS/MS 3
Agilent 1100 LC/G3250AA TOF MSD (LC TOF) 1
Applied Biosystems Voyager DE PRO MALDI-TOF 1
Agilent LC-TOF 1
Waters Quattro Micro LC/MS/MS 1
Agilent GC/MS 2
Gas Chromatography
Agilent GCs 22
Headspace Autosampler 5
Elemental Analysis
PE Optima 3000 Inductively Coupled Plasma (ICP-OES) Spectrophotometer 1
PE Elan 9000 ICP/MS 1
PE Graphite Furnace Atomic Absorption Spectrometer 1
PE Analyst 800 Flame Atomic Absorption Spectrometer 1
PE CHN Analyzer 1
Spectrophotometry
Bio-Rad Excalibur FTS 3000 Fourier Tranform Infrared Spectrophotometer (FTIR) 1
Thermo Scientific /Agilent 8453 UV/VIS Spectrophotometer 8
Jasco J-815 Spectropolarimeter 1
Molecular Biology/Cell Biology/Virology
Applied Biosystem 7500 FAST qPCR systems 2
Thermo Scientific controlled rate freezer 1
Nanodrop 1000 (Thermofisher) 1
Becton Dickinson FACScalibur Flow Cytometer 1
Plate Reader (Molecular Devices M2 and M5e) 3
Vi Cell Automated Cell Counter (Beckman Coulter) 1
Tissue culture and virology laboratories with controlled access equipped with HEPA filtration and BSL2 capabilities -
ISO 7 Cell bank manufacturing suites 2
GE AKTA Purifier 100 Chromatography Systems (FPLC) 2
Viral Clearance Suites - dedicated, with controlled access and equipped with HEPA filtration 2
Miscellaneous Pharmaceutical/ Biopharmaceutical
Volumetric Karl Fisher (KF) Systems 4
Coulometric KF Systems 4
Coulometric KF Systems with oven 1
Thin Layer Chromatography (TLC) Sampler 1
Thin Layer Chromatography Digital Camera 1
Polarimeter 1
Refractometer 1
Rotational Viscometer 3
Electronic Titrator 3
Dissolution Baths (Apparatus 1,2,4,5, and 7) (Distek/Varian/Sotax)

    18 with semi-automated pulling systems, 2 APP 4 systems, 2 APP 7 systems,
    1-mini-vessel system
39
GE Analytical/Sievers 900/800 Total Organic Carbon Analyzer (TOC) 3
Differential Scanning Calorimeter (DSC) 1
Thermo Gravimetric Analyzer (TGA) 1
Cascade Impaction 2
Ion Mobility Spectroscopy (IMS) 1
Stability Chambers (22,000 ft3) 34
Microbiology
Microbiology laboratories with controlled access, equipped with HEPA filtration and BSL2 capabilities
la Calhene soft wall isolator system
    two half-suit workstations
2
    three-glove transfer isolators
2
    two-glove transfer isolators
2
    one half-suit autoclave isolator interface
1
Millipore Integral Steritest™ systems for membrane filtration 2
Steris VHP® 1000 systems for decontamination 3
GC based microbial identification systems (MIS) 2
Dupont Qualicon Riboprinter® Microbial Identification System 1
HIAC \Royco particle counters 2
Endoscan-V system for performing kinetic turbidimetric/chromogenic endotoxin tests 2
Aqualab water activity meter 1
Metrology
Full-time metrologists and extensive in-house preventive maintenance 8

Updated 2-03-10